Orenburg's main airport services flights to/from Moscow, Saint Petersburg, and Dushanbe
There are two trains from Moscow to Orenburg.One of them departs every odd day around 19:00 and takes 26 hours.And the second one departs every day per week around 15:00 and takes 30 hours.
Trains goes through Ryazan, Samara.
There is one train goes every day from and to Samara.